The Kansas City Chiefs are facing a potential setback as they prepare to meet the Buffalo Bills on October 29, 2025. Starting running back Isiah Pacheco is at risk of missing the game due to a knee injury sustained during a recent match against the Washington Commanders. This development could significantly impact the Chiefs’ offensive strategy against a formidable opponent.
Pacheco, who has been a key contributor this season, left the game on October 23, 2025, and is currently classified as week-to-week, according to NFL Network reporter Tom Pelissero. In the first eight weeks of the season, he has led the Chiefs with 78 carries for 329 yards rushing, along with 11 receptions for 43 yards and a touchdown. His absence would leave a notable gap in the Chiefs’ running game, particularly against a Bills defense that has struggled this season.
In the game against the Commanders, Pacheco managed to carry the ball 12 times for 58 yards before his exit. His backup, Kareem Hunt, stepped up by finishing the game with nine carries for 40 yards and a touchdown, indicating that the Chiefs have some depth in their backfield. Hunt has accumulated 62 carries for 245 yards and four touchdowns this season, showing his capability to handle increased responsibilities if necessary.
The Buffalo Bills, on the other hand, are dealing with their own challenges in the defensive lineup. Their run defense has been notably weak, allowing an average of 150.3 yards rushing per game, the second-most in the NFL. Key defensive tackle players such as Ed Oliver, T.J. Sanders, and DeWayne Carter are currently on injured reserve, while DaQuan Jones is recovering from injury. This situation raises questions about the Bills’ ability to defend against the Chiefs’ running game, especially if Pacheco is unavailable.
The outcome of this matchup could hinge on how effectively both teams adapt to these injuries. With the Bills managing a porous run defense and the Chiefs potentially missing their primary running back, the game is shaping up to be a crucial test for both squads.
As the teams gear up for this highly anticipated clash, fans and analysts alike will be watching closely to see how these injury concerns influence the strategies on both sides. The importance of this game extends beyond just a win or loss; it could have significant implications for playoff positioning as the season progresses.
